Biopsychosocial and Structural Determinants of Chemical Addictions in Prison Settings
Iskandarov R.R. Biopsychosocial and structural determinants of chemical addictions in prison settings. Penitentiary Science, 2025, vol. 19, no. 2 (70), pp. 189–199. doi 10.46741/2686-9764.2025.70.2.009.
Substance use disorders among prisoners are a multi-level problem caused by the interaction of neurobiological, psychological and social factors. The problem of addiction among persons in places of imprisonment is widespread and has a significant impact on both the individuals themselves and the prison system as a whole. High recidivism rates among prisoners with addictions and low efficiency of traditional approaches to rehabilitation require in-depth interdisciplinary analysis. Numerous studies indicate high levels of chronic stress experienced by prisoners, which necessitates consideration of the relationship between chronic stress and maintenance of addiction in this population. High comorbidity of addiction and incarceration necessitates a deeper understanding of the underlying factors, such as stress, to develop effective intervention strategies. Purpose: to study mechanisms of addiction formation and maintenance in the penitentiary system, analyze the influence of chronic stress on neurochemical processes, cognitive-emotional patterns and social determinants, to substantiate the key importance of chronic stress compared to other factors in maintaining addiction, and to develop expanded recommendations for rehabilitation. Methods: an in-depth review and analysis of current scientific publications containing empirical data on the prevalence and impact of chronic stress, its relationship with addiction in convicts, and the effectiveness of various rehabilitation approaches was conducted. Results: it is revealed that prison conditions (sensory deprivation, limited autonomy, harsh conditions, and violence) provoke chronic stress in convicts, which aggravates neurobiological disorders (dysfunction of the dopamine system, hypercortisolemia, and suppression of neurogenesis) and epigenetic changes associated with these disorders. Chronic stress is a key factor in the maintenance and relapse of addiction, provoking cravings and contributing to the use of psychoactive substances as a means of self-medication. Psychological factors (learned helplessness, distorted time perspective, and emotional dysregulation) and social risks (stigmatization, isolation, and lack of reintegration programs) closely interact with stress, forming a cycle of maladaptation. The effectiveness of complex strategies combining psychological interventions (cognitive behavioral therapy, mindfulness therapy), social support (reintegration programs, family involvement, and mentoring) and, if necessary, pharmacotherapy is confirmed. Conclusion: chronic stress plays a key role in maintaining addiction in convicts. Optimization of rehabilitation requires the integration of neuroscientific data, psychocorrectional methods (cognitive behavioral therapy, mindfulness therapy, and a trauma-informed approach) and socio-environmental approaches (reintegration programs, family support, mentors, and social workers). Promising are complex programs aimed at reducing allostatic load, developing coping strategies, restoring neuroplasticity and ensuring continuity of support after release.
Keywords: chemical dependencies; convicts; penal system; chronic stress; rehabilitation; recidivism; psychological interventions; social support.
org/unodc/data-and-analysis/world-drug-report-2024.html (accessed April 20, 2025).
2. Report on the drug situation in the Russian Federation in 2023. Gosudarstvennyi antinarkoticheskii komitet [State AntiDrug Committee]. 2023. Available at: https://media.mvd.ru/files/embed/6440403 (In Russ.) (Accessed April 20, 2025).
3. Iskandarov R.R. Psychoactive substances as a factor in committing violent crimes: the current state of the problem.
Narkologiya = Narcology, 2024, no. 23 (1), pp. 42–45.
4. Brief description of the crime situation in 2024. MVD Rossii [The Ministry of the Interior of Russia]. 2024. Available at:
https://mvd.rf/reports/index/ (In Russ.). (Accessed April 20, 2025).
5. Chandler R.K., Fletcher B.W., Volkow N.D. Treating drug abuse and addiction in the criminal justice system: improving
public health and safety. JAMA, 2009, vol. 301, no. 2, pp. 183–190.
6. McEwen B.S. Neurobiological and systemic effects of chronic stress. Chronic Stress (Thousand Oaks), 2017, vol. 1,
art. 2470547017692328.
7. Volkow N.D., Fowler D.S., Wang G.D. Neurobiologic advances from the brain disease model of addiction. The New
England Journal of Medicine, 2016, vol. 374, no. 4, pp. 363–371.
8. Goomany A., Dickinson T. The influence of prison climate on the mental health of adult prisoners: a literature review.
Journal of Psychiatric and Mental Health Nursing, 2015, vol. 22, no. 6, pp. 413–422.
9. Brinded P.M. et al. Prevalence of psychiatric disorders in New Zealand prisons: a national study. The Australian and New
Zealand Journal of Psychiatry, 2001, vol. 35, pp. 166–173.
10. Brugha T. et al. Psychosis in the community and in prisons: a report from the British National Survey of psychiatric
morbidity. The American Journal of Psychiatry, 2005, vol. 162, pp. 774–780. (In Russ.).
11. Schnittker J., Massoglia M., Uggen C. Out and down: incarceration and psychiatric disorders. Journal of Health and
Social Behavior, 2012, vol. 53, no. 4, pp. 448–464.
12. Baker O. et al. Experience delivering an integrated service model to people with criminal justice system involvement and
housing insecurity. BMC Public Health, 2023, vol. 23, art. 222.
13. Morenoff J.D., Harding D.J. Incarceration, prisoner reentry, and communities. Annual Review of Sociology, 2014,
vol. 40, pp. 411–429.
14. Seligman M.E. Learned helplessness. Annual Review of Medicine, 1972, vol. 23, pp. 407–412.
15. Zimbardo P.G., Boyd J.N. Putting time in perspective: a valid, reliable individual-differences metric. Journal of Personality
and Social Psychology, 1999, vol. 77, no. 6, pp. 1,271–1,288.
16. Crewe B. The Prisoner Society: Power, Adaptation and Social Life in an English Prison. Oxford, 2012. 528 p.
17. Ansah E.W. et al. Assessing stress levels, predictors and management strategies of inmates at Ankaful Prison Complex
in the central region, Ghana. Behavioral Sciences, 2023, vol. 13, no. 3, p. 201.
18. Edgemon T.G., Clay-Warner J. Inmate mental health and the pains of imprisonment. Society and Mental Health, 2018,
vol. 9, no. 1, pp. 33–50.
19. Lindquist C.H., Lindquist C.A. Gender differences in distress: mental health consequences of environmental stress
among jail inmates. Behavioral Sciences & the Law, 1997, vol. 15, no. 4, pp. 503–523.
20. Palmer E.J., Connelly R. Depression, hopelessness and suicide ideation among vulnerable prisoners. Criminal Behaviour
and Mental Health: CBMH, 2005, vol. 15, no. 3, pp. 164–170.
21. Solbakken L.E., Wynn R. Barriers and opportunities to accessing social support in the transition from community to
prison: a qualitative interview study with incarcerated individuals in Northern Norway. BMC Psychology, 2022, vol. 10,
art. 185.
22. Evans G. W. The built environment and mental health. Journal of Urban Health: Bulletin of the New York Academy of
Medicine, 2003, vol. 80, pp. 536–555.
23. Nurse J., Woodcock P., Ormsby J. Influence of environmental factors on mental health within prisons: focus group study.
BMJ, 2003, vol. 327, no. 7,413, pp. 480.
24. Boxer P., Middlemass K., Delorenzo T. Exposure to violent crime during incarceration: effects on psychological
adjustment following release. Criminal Justice and Behavior, 2009, vol. 36, no. 8, pp. 793–807.
25. Piper A., Berle D. The association between trauma experienced during incarceration and PTSD outcomes: a systematic
review and meta-analysis. Journal of Forensic Psychiatry and Psychology, 2019, vol. 30, no. 5, pp. 854–875.
26. Andersen H.S. et al. A longitudinal study of prisoners on remand: psychiatric prevalence, incidence and psychopathology
in solitary vs. non-solitary confinement. Acta psychiatrica Scandinavica, 2000, vol. 102, № 1. p. 19–25.
27. Vyalova N.M., Levchuk L.A. The role of BDNF in the development of depressive disorders. Fundamental’nye issledovaniya
= Fundamental Research, 2014, no. 10–4, pp. 771–775. (In Russ.).
28. Andersen A.M. et al. Current and future prospects for epigenetic biomarkers of substance use disorders. Genes (Basel),
2015, vol. 6, no. 4, pp. 991–1,022.
29. Bohacek J., Mansuy I.M. Molecular insights into transgenerational non-genetic inheritance of acquired behaviours.
Nature Reviews Genetics, 2015, vol. 16, no. 11, pp. 641–652.
30. Tanabe J. et al. Prefrontal cortex activity is reduced in gambling and nongambling substance users during decisionmaking. Human Brain Mapping, 2007, vol. 28, no. 12, pp. 1,276–1,286.
31. Zika S., Chamberlain K. On the relation between meaning in life and psychological well-being. British Journal of
Psychology, 1992, vol. 83, pp. 133–145.
32. Reynolds B. A review of delay-discounting research with humans: relations to drug use and gambling. Behavioural
Pharmacology, 2006, vol. 17, no. 8, pp. 651–667.
33. D’yakov D.G., Zhuk N. N., Malakhovskaya E. S. Self-identification of patients suffering from mental and behavioral
disorders due to the use of different types of psychoactive substances: comparative analyses. Sibirskii psikhologicheskii
zhurnal = Siberian Psychological Journal, 2016, no. 59, pp. 85–107. (In Russ.).
34. Nejad A.B., Fossati P., Lemogne C. Self-referential processing, rumination, and cortical midline structures in major
depression. Frontiers in Human Neuroscience, 2013, vol. 7, art. 666.
35. Degenhardt L. et al. Global patterns of opioid use and dependence: harms to populations, interventions, and future
action. Lancet, 2019, vol. 394, pp. 1,560–1,579.
36. Iacobucci G. Prisoners die from natural causes 20 years earlier than the general population, finds review. BMJ, 2024,
vol. 384, pp. 198.
37. Trauma-informed care in behavioral health services. Center for Substance Abuse Treatment (US). Rockville (MD):
Substance Abuse and Mental Health Services Administration (US). 2014.
38. Fischer J. Deep Control: Essays on Free Will and Value, Oxford, 2012. 243 p.
39. Churchland Braintrust. What Neuroscience Tells Us About Morality. Rivista Italiana di Filosofia Analitica Junior, 2012,
vol. 3, p. 10.
40. Foucault M. Surveiller et punir: Naissance de la prison. Paris, 1975. 328 p. (In French).
41. Levinas E. Izbrannoe. Total’nost’ i Beskonechnoe [Selected works. Totality and the Infinite]. Moscow; Saint Petersburg,
2000. 416 p.
42. Solbakken L.E., Wynn R. Barriers and opportunities to accessing social support in the transition from community to
prison: a qualitative interview study with incarcerated individuals in Northern Norway. BMC Psychol, 2022, vol. 10, art. 185.